| Host: |
Goat |
| Applications: |
Pep-ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-Slc8a3-Mouse (N-Term) is suitable for use in ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:64000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
Slc8a3 |
| Gene ID: |
110893 |
| Uniprot ID: |
NAC3_MOUSE |
| Immunogen Region: |
N-Term |
| Accession Number: |
NP_001161392.1; NP_536688.2 |
| Specificity: |
This antibody is expected to recognize both reported isoforms (NP_001161392.1; NP_536688.2). |
| Immunogen Sequence: |
CLRAEAGDSGDVPS |
| Function | Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Required for normal oligodendrocyte differentiation and for normal myelination. Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis. Isoform 1 displays higher calcium exchanger activity than isoform 2, probably because isoform 1 has a lower threshold for activation by cytoplasmic Ca(2+). |
| Protein Name | Sodium/Calcium Exchanger 3Na(+/Ca(2+-Exchange Protein 3Solute Carrier Family 8 Member 3 |
| Database Links | Reactome: R-MMU-418359Reactome: -MMU-425561Reactome: -MMU-5578775 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPerikaryonCell ProjectionDendriteDendritic SpineSarcolemmaCytoplasmSarcoplasmCell JunctionMitochondrion Outer MembranePerinuclear RegionEndoplasmic Reticulum MembraneDetected At Neuromuscular JunctionsIsoform 1: Cell MembraneIsoform 2: Cell Membrane |
| Alternative Antibody Names | Anti-Sodium/Calcium Exchanger 3 antibodyAnti-Na(+/Ca(2+-Exchange Protein 3 antibodyAnti-Solute Carrier Family 8 Member 3 antibodyAnti-Slc8a3 antibodyAnti-Ncx3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
