• STJ73535 (0. 3µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Detected by chemiluminescence

Anti-SLC7A6/y+LAT-2 antibody (C-Term) (STJ73535)

SKU:
STJ73535-100

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Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-SLC7A6/y+LAT-2 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.3-1µg/ml
IHC-5µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: SLC7A6
Gene ID: 9057
Uniprot ID: YLAT2_HUMAN
Immunogen Region: C-Term
Accession Number: NP_003974.3
Specificity: Reported variants represent identical protein: NP_003974.3, NP_001070253.1
Immunogen Sequence: ELDVAEEKKDERKTD
Function Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis. Also exchanges L-arginine with L-lysine in a sodium-independent manner. The transport mechanism is electroneutral and operates with a stoichiometry of 1:1. Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration. May mediate transport of ornithine in retinal pigment epithelial (RPE) cells. May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte.
Protein Name Y+L Amino Acid Transporter 2
Cationic Amino Acid Transporter - Y+ System
Solute Carrier Family 7 Member 6
Y(+L-Type Amino Acid Transporter 2
Y+Lat2
Y+Lat-2
Database Links Reactome: R-HSA-210991
Reactome: R-HSA-352230
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Y+L Amino Acid Transporter 2 antibody
Anti-Cationic Amino Acid Transporter - Y+ System antibody
Anti-Solute Carrier Family 7 Member 6 antibody
Anti-Y(+L-Type Amino Acid Transporter 2 antibody
Anti-Y+Lat2 antibody
Anti-Y+Lat-2 antibody
Anti-SLC7A6 antibody
Anti-KIAA0245 antibody

Information sourced from Uniprot.org

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