Anti-SLC7A6 antibody (STJA0009241)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SLC7A6
General Information
| Short Description | Rabbit polyclonal anti-Y+L amino acid transporter 2L-type amino acid transporter 2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC7A6 |
| Gene ID | 9057 |
| Uniprot ID | YLAT2_HUMAN |
| Immunogen | Synthesized peptide derived from human SLC7A6 |
| Specificity | This antibody detects endogenous levels of SLC7A6 at Human, Mouse |
Additional Info
| Function | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis. Also exchanges L-arginine with L-lysine in a sodium-independent manner. The transport mechanism is electroneutral and operates with a stoichiometry of 1:1. Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration. May mediate transport of ornithine in retinal pigment epithelial (RPE) cells. May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte. |
| Protein Name | Y+L Amino Acid Transporter 2Cationic Amino Acid Transporter - Y+ SystemSolute Carrier Family 7 Member 6Y(+L-Type Amino Acid Transporter 2Y+Lat2Y+Lat-2 |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-352230 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Y+L Amino Acid Transporter 2 antibodyAnti-Cationic Amino Acid Transporter - Y+ System antibodyAnti-Solute Carrier Family 7 Member 6 antibodyAnti-Y(+L-Type Amino Acid Transporter 2 antibodyAnti-Y+Lat2 antibodyAnti-Y+Lat-2 antibodyAnti-SLC7A6 antibodyAnti-KIAA0245 antibody |
Information sourced from Uniprot.org