Anti-SLC6A3 antibody (1-100) (STJ117430)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC6A3 (1-100) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:100IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC6A3 |
| Gene ID | 6531 |
| Uniprot ID | SC6A3_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MSKSKCSVGLMSSVVAPAKE PNAVGPKEVELILVKEQNGV QLTSSTLTNPRQSPVEAQDR ETWGKKIDFLLSVIGFAVDL ANVWRFPYLCYKNGGGAFLV |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Dopamine Transporter/SLC6A3 (NP_001035.1). |
Additional Info
| Tissue Specificity | Highly expressed in substantia nigra. Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level). Expressed in the striatum (at protein level). |
| Function | Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling. |
| Protein Name | Sodium-Dependent Dopamine TransporterDa TransporterDatSolute Carrier Family 6 Member 3 |
| Database Links | Reactome: R-HSA-379401Reactome: R-HSA-442660Reactome: R-HSA-5619081Reactome: R-HSA-5660724 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionNeuron ProjectionAxonLocalizes To Neurite Tips In Neuronal CellsColocalizes With Septin4 At Axon TerminalsEspecially At The Varicosities |
| Alternative Antibody Names | Anti-Sodium-Dependent Dopamine Transporter antibodyAnti-Da Transporter antibodyAnti-Dat antibodyAnti-Solute Carrier Family 6 Member 3 antibodyAnti-SLC6A3 antibodyAnti-DAT1 antibody |
Information sourced from Uniprot.org