Anti-SLC5A8 antibody (STJ13100364)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from human SLC5A8 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-SLC5A8 for use in IHC and WB in Human and Marmoset samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Marmoset |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1: 1000 for IHC-P and 1:2000 for WB is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | SLC5A8 |
| Gene ID | 160728 |
| Uniprot ID | SC5A8_HUMAN |
| Immunogen | A synthetic peptide from human SLC5A8 conjugated to blue carrier protein was used as the antigen. |
| Specificity | Specific for SLC5A8. |
Additional Info
| Function | Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline). Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced. |
| Protein Name | Sodium-Coupled Monocarboxylate Transporter 1Apical Iodide TransporterElectrogenic Sodium Monocarboxylate CotransporterSodium Iodide-Related CotransporterSolute Carrier Family 5 Member 8 |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-428643 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinExpressed At The Apical Membrane Of Normal Tall Thyrocytes And Of Colonic Epithelial Cells |
| Alternative Antibody Names | Anti-Sodium-Coupled Monocarboxylate Transporter 1 antibodyAnti-Apical Iodide Transporter antibodyAnti-Electrogenic Sodium Monocarboxylate Cotransporter antibodyAnti-Sodium Iodide-Related Cotransporter antibodyAnti-Solute Carrier Family 5 Member 8 antibodyAnti-SLC5A8 antibodyAnti-AIT antibodyAnti-SMCT antibodyAnti-SMCT1 antibody |
Information sourced from Uniprot.org