| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sodium-coupled monocarboxylate transporter 1 (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC5A8 |
| Gene ID: |
160728 |
| Uniprot ID: |
SC5A8_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
This antibody detects endogenous levels of SC5A8 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human C-ternal SC5A8 |
| Function | Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline). Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced. |
| Protein Name | Sodium-Coupled Monocarboxylate Transporter 1Apical Iodide TransporterElectrogenic Sodium Monocarboxylate CotransporterSodium Iodide-Related CotransporterSolute Carrier Family 5 Member 8 |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-428643 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinExpressed At The Apical Membrane Of Normal Tall Thyrocytes And Of Colonic Epithelial Cells |
| Alternative Antibody Names | Anti-Sodium-Coupled Monocarboxylate Transporter 1 antibodyAnti-Apical Iodide Transporter antibodyAnti-Electrogenic Sodium Monocarboxylate Cotransporter antibodyAnti-Sodium Iodide-Related Cotransporter antibodyAnti-Solute Carrier Family 5 Member 8 antibodyAnti-SLC5A8 antibodyAnti-AIT antibodyAnti-SMCT antibodyAnti-SMCT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
