Anti-SLC5A8 antibody (C-Term) (STJA0010342)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human C-ternal SC5A8
General Information
| Short Description | Rabbit polyclonal anti-Sodium-coupled monocarboxylate transporter 1 (C-Term) for use in IHC and WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC5A8 |
| Gene ID | 160728 |
| Uniprot ID | SC5A8_HUMAN |
| Immunogen | Synthesized peptide derived from human C-ternal SC5A8 |
| Immunogen Region | C-Term |
| Specificity | This antibody detects endogenous levels of SC5A8 at Human, Mouse |
Additional Info
| Function | Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline). Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced. |
| Protein Name | Sodium-Coupled Monocarboxylate Transporter 1Apical Iodide TransporterElectrogenic Sodium Monocarboxylate CotransporterSodium Iodide-Related CotransporterSolute Carrier Family 5 Member 8 |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-428643 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinExpressed At The Apical Membrane Of Normal Tall Thyrocytes And Of Colonic Epithelial Cells |
| Alternative Antibody Names | Anti-Sodium-Coupled Monocarboxylate Transporter 1 antibodyAnti-Apical Iodide Transporter antibodyAnti-Electrogenic Sodium Monocarboxylate Cotransporter antibodyAnti-Sodium Iodide-Related Cotransporter antibodyAnti-Solute Carrier Family 5 Member 8 antibodyAnti-SLC5A8 antibodyAnti-AIT antibodyAnti-SMCT antibodyAnti-SMCT1 antibody |
Information sourced from Uniprot.org