| Function | Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline). Can mediate the transport of chloride, bromide, iodide and nitrate ions when external concentration of sodium ions is reduced. |
| Protein Name | Sodium-Coupled Monocarboxylate Transporter 1Electrogenic Sodium Monocarboxylate CotransporterSolute Carrier Family 5 Member 8 |
| Database Links | Reactome: R-MMU-197264Reactome: -MMU-428643 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinRestricted To The Apical Cell Membrane Of Enterocytes |
| Alternative Antibody Names | Anti-Sodium-Coupled Monocarboxylate Transporter 1 antibodyAnti-Electrogenic Sodium Monocarboxylate Cotransporter antibodyAnti-Solute Carrier Family 5 Member 8 antibodyAnti-Slc5a8 antibodyAnti-Smct antibodyAnti-Smct1 antibody |
Information sourced from Uniprot.org
