Anti-SLC5A8 antibody (C-Term) (STJ13102142)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from c-terminal region of mouse Sodium coupled monocarboxylate transporter 1 (SLC5A8) conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-SLC5A8 (C-Term) for use in IHC and WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Slc5a8 |
| Gene ID | 216225 |
| Uniprot ID | SC5A8_MOUSE |
| Immunogen | A synthetic peptide from c-terminal region of mouse Sodium coupled monocarboxylate transporter 1 (SLC5A8) conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | C-Term |
| Specificity | Specific for SLC5A8. |
Additional Info
| Function | Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline). Can mediate the transport of chloride, bromide, iodide and nitrate ions when external concentration of sodium ions is reduced. |
| Protein Name | Sodium-Coupled Monocarboxylate Transporter 1Electrogenic Sodium Monocarboxylate CotransporterSolute Carrier Family 5 Member 8 |
| Database Links | Reactome: R-MMU-197264Reactome: -MMU-428643 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinRestricted To The Apical Cell Membrane Of Enterocytes |
| Alternative Antibody Names | Anti-Sodium-Coupled Monocarboxylate Transporter 1 antibodyAnti-Electrogenic Sodium Monocarboxylate Cotransporter antibodyAnti-Solute Carrier Family 5 Member 8 antibodyAnti-Slc5a8 antibodyAnti-Smct antibodyAnti-Smct1 antibody |
Information sourced from Uniprot.org