Anti-SLC5A6 antibody (551-600 aa) (STJ95714)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human SLC5A6 at the amino acid range 551-600
General Information
| Short Description | Rabbit polyclonal anti-Sodium-dependent multivitamin transporter-dependent multivitamin transporter (551-600 aa) for use in WB, ELISA and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC5A6 |
| Gene ID | 8884 |
| Uniprot ID | SC5A6_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human SLC5A6 at the amino acid range 551-600 |
| Immunogen Region | 551-600 aa |
| Specificity | SMVT Polyclonal Antibody detects endogenous levels of SMVT protein. |
Additional Info
| Post Translational Modifications | May be glycosylated. |
| Function | Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide. Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake. Required for biotin and pantothenate uptake in the intestine across the brush border membrane. Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin. Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier. |
| Protein Name | Sodium-Dependent Multivitamin TransporterNa(+-Dependent Multivitamin TransporterHsmvtSolute Carrier Family 5 Member 6 |
| Database Links | Reactome: R-HSA-196780Reactome: R-HSA-199220Reactome: R-HSA-425397 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembranePreferentially Localized At The Luminal Membrane Of Brain Capillary EndotheliumLocalized To The Brush Border/Apical Membrane Of Intestine And Renal Polarized Cells(Microbial Infection) Exposure To EColi Lipopolysaccharides Leads To Reduced Cell Membrane Localization |
| Alternative Antibody Names | Anti-Sodium-Dependent Multivitamin Transporter antibodyAnti-Na(+-Dependent Multivitamin Transporter antibodyAnti-Hsmvt antibodyAnti-Solute Carrier Family 5 Member 6 antibodyAnti-SLC5A6 antibodyAnti-SMVT antibody |
Information sourced from Uniprot.org