| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Sodium-dependent multivitamin transporter-dependent multivitamin transporter (551-600 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-P 1:50-300 ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC5A6 |
| Gene ID: | 8884 |
| Uniprot ID: | SC5A6_HUMAN |
| Immunogen Region: | 551-600 aa |
| Specificity: | SMVT Polyclonal Antibody detects endogenous levels of SMVT protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human SLC5A6 at the amino acid range 551-600 |
| Post Translational Modifications | May be glycosylated. |
| Function | Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide. Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake. Required for biotin and pantothenate uptake in the intestine across the brush border membrane. Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin. Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier. |
| Protein Name | Sodium-Dependent Multivitamin Transporter Na(+-Dependent Multivitamin Transporter Hsmvt Solute Carrier Family 5 Member 6 |
| Database Links | Reactome: R-HSA-196780 Reactome: R-HSA-199220 Reactome: R-HSA-425397 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Apical Cell Membrane Preferentially Localized At The Luminal Membrane Of Brain Capillary Endothelium Localized To The Brush Border/Apical Membrane Of Intestine And Renal Polarized Cells (Microbial Infection) Exposure To E Coli Lipopolysaccharides Leads To Reduced Cell Membrane Localization |
| Alternative Antibody Names | Anti-Sodium-Dependent Multivitamin Transporter antibody Anti-Na(+-Dependent Multivitamin Transporter antibody Anti-Hsmvt antibody Anti-Solute Carrier Family 5 Member 6 antibody Anti-SLC5A6 antibody Anti-SMVT antibody |
Information sourced from Uniprot.org