| Post Translational Modifications | May be glycosylated. |
| Function | Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide. Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake. Required for biotin and pantothenate uptake in the intestine across the brush border membrane. Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin. Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier. |
| Protein Name | Sodium-Dependent Multivitamin TransporterNa(+-Dependent Multivitamin TransporterHsmvtSolute Carrier Family 5 Member 6 |
| Database Links | Reactome: R-HSA-196780Reactome: R-HSA-199220Reactome: R-HSA-425397 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembranePreferentially Localized At The Luminal Membrane Of Brain Capillary EndotheliumLocalized To The Brush Border/Apical Membrane Of Intestine And Renal Polarized Cells(Microbial Infection) Exposure To EColi Lipopolysaccharides Leads To Reduced Cell Membrane Localization |
| Alternative Antibody Names | Anti-Sodium-Dependent Multivitamin Transporter antibodyAnti-Na(+-Dependent Multivitamin Transporter antibodyAnti-Hsmvt antibodyAnti-Solute Carrier Family 5 Member 6 antibodyAnti-SLC5A6 antibodyAnti-SMVT antibody |
Information sourced from Uniprot.org
