Anti-SLC5A10 antibody (ECD) (STJ13102193)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from 1t extracellular domain of human SLC5A10 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-SLC5A10 (ECD) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | SLC5A10 |
| Gene ID | 125206 |
| Uniprot ID | SC5AA_HUMAN |
| Immunogen | A synthetic peptide from 1t extracellular domain of human SLC5A10 conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | ECD |
| Specificity | Specific for SLC5A10. |
Additional Info
| Function | Isoform 1: Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2. Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins. Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney. Isoform 2: Appears to have no transporter activity. |
| Protein Name | Sodium/Mannose Cotransporter Slc5a10Sodium/Glucose Cotransporter 5Na(+/Glucose Cotransporter 5Solute Carrier Family 5 Member 10 |
| Database Links | Reactome: R-HSA-189200 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium/Mannose Cotransporter Slc5a10 antibodyAnti-Sodium/Glucose Cotransporter 5 antibodyAnti-Na(+/Glucose Cotransporter 5 antibodyAnti-Solute Carrier Family 5 Member 10 antibodyAnti-SLC5A10 antibodyAnti-SGLT5 antibody |
Information sourced from Uniprot.org