| Post Translational Modifications | N-glycosylation is not necessary for the cotransporter function. |
| Function | Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis. Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules. Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception. Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine. |
| Protein Name | Sodium/Glucose Cotransporter 1Na(+/Glucose Cotransporter 1High Affinity Sodium-Glucose CotransporterSolute Carrier Family 5 Member 1 |
| Database Links | Reactome: R-HSA-189200Reactome: R-HSA-5656364Reactome: R-HSA-8981373 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative Nanobody Names | Anti-Sodium/Glucose Cotransporter 1 nanobodyAnti-Na(+/Glucose Cotransporter 1 nanobodyAnti-High Affinity Sodium-Glucose Cotransporter nanobodyAnti-Solute Carrier Family 5 Member 1 nanobodyAnti-SLC5A1 nanobodyAnti-NAGT nanobodyAnti-SGLT1 nanobody |
Information sourced from Uniprot.org
![Anti-SLC5A1 nanobody [SAA0963] (STJN000149)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200762/412944/STJN000149-SDS-PAGE-1__80583.1749232474.jpg?c=1 "Anti-SLC5A1 nanobody [SAA0963] (STJN000149)")
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