Anti-SLC5A1 antibody (603-623) {FITC} (STJ502990)

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STJ502990-100

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Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity: Human/Monkey/Mouse/Rat/Sheep
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SLC5A1 (603-623) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55 µg/µl
Dilution Range: WB: 1:500-1:1, 000
DB: 1:4, 000
ELISA: 1:4, 000
IP: 1:200
IHC: 1:250
ICC: 1:250
IF: 1:250
CFM: 1:250
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SLC5A1
Gene ID: 6523
Uniprot ID: SC5A1_HUMAN
Immunogen Region: 603-623
Immunogen: Synthetic peptide corresponding to amino acids 603-623 of Human SGLT1.
Tissue Specificity Expressed in intestine. Expressed in endometrial cells.
Post Translational Modifications N-glycosylation is not necessary for the cotransporter function.
Function Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis. Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules. Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception. Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine.
Protein Name Sodium/Glucose Cotransporter 1
Na(+/Glucose Cotransporter 1
High Affinity Sodium-Glucose Cotransporter
Solute Carrier Family 5 Member 1
Database Links Reactome: R-HSA-189200
Reactome: R-HSA-5656364
Reactome: R-HSA-8981373
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Sodium/Glucose Cotransporter 1 antibody
Anti-Na(+/Glucose Cotransporter 1 antibody
Anti-High Affinity Sodium-Glucose Cotransporter antibody
Anti-Solute Carrier Family 5 Member 1 antibody
Anti-SLC5A1 antibody
Anti-NAGT antibody
Anti-SGLT1 antibody

Information sourced from Uniprot.org

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