Anti-SLC4A8 antibody (1-90) (STJ117025)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC4A8 (1-90) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC4A8 |
| Gene ID | 9498 |
| Uniprot ID | S4A8_HUMAN |
| Immunogen Region | 1-90 |
| Immunogen Sequence | MPAAGSNEPDGVLSYQRPDE EAVVDQGGTSTILNIHYEKE ELEGHRTLYVGVRMPLGRQS HRHHRTHGQKHRRRGRGKGA SQGEEGLEAL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human SLC4A8 (NP_001035049.1). |
Additional Info
| Tissue Specificity | Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex. Isoform 1: Expressed in the brain. Isoform 4: Expressed in the brain, heart and kidney. Isoform 5: Expressed in the brain, heart and kidney. |
| Function | Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. Mediates sodium reabsorption in the renal cortical collecting ducts. |
| Protein Name | Electroneutral Sodium Bicarbonate Exchanger 1Electroneutral Na(+-Driven Cl-Hco3 ExchangerSolute Carrier Family 4 Member 8K-Nbc3 |
| Database Links | Reactome: R-HSA-425381 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneIsoform 1: Cell MembraneIsoform 3: Cell MembraneIsoform 4: Cell MembraneIsoform 5: Cell Membrane |
| Alternative Antibody Names | Anti-Electroneutral Sodium Bicarbonate Exchanger 1 antibodyAnti-Electroneutral Na(+-Driven Cl-Hco3 Exchanger antibodyAnti-Solute Carrier Family 4 Member 8 antibodyAnti-K-Nbc3 antibodyAnti-SLC4A8 antibodyAnti-KIAA0739 antibodyAnti-NBC antibodyAnti-NBC3 antibodyAnti-NDCBE1 antibody |
Information sourced from Uniprot.org