| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC4A2 (200-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC4A2 |
| Gene ID: |
6522 |
| Uniprot ID: |
B3A2_HUMAN |
| Immunogen Region: |
200-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human SLC4A2 (NP_001186623.1). |
| Immunogen Sequence: |
DDGGASGRPLPKAQPGHRSY NLQERRRIGSMTGAEQALLP RVPTDEIEAQTLATADLDLM KSHRFEDVPGVRRHLVRKNA KGSTQSGREGREPGPTPRAR P |
| Tissue Specificity | Isoform A: Expressed in the liver, stomach, kidney, prostate, thyroid and rectum. Isoform B1: Expressed in the liver and kidney. Isoform B2: Expressed in the liver and kidney. |
| Function | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane. Plays an important role in osteoclast differentiation and function. Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH. Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses. |
| Protein Name | Anion Exchange Protein 2Ae 2Anion Exchanger 2Non-Erythroid Band 3-Like ProteinBnd3lSolute Carrier Family 4 Member 2 |
| Database Links | Reactome: R-HSA-425381 |
| Cellular Localisation | Isoform A: Apical Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneIsoform B1: Apical Cell MembraneIsoform B2: Apical Cell Membrane |
| Alternative Antibody Names | Anti-Anion Exchange Protein 2 antibodyAnti-Ae 2 antibodyAnti-Anion Exchanger 2 antibodyAnti-Non-Erythroid Band 3-Like Protein antibodyAnti-Bnd3l antibodyAnti-Solute Carrier Family 4 Member 2 antibodyAnti-SLC4A2 antibodyAnti-AE2 antibodyAnti-EPB3L1 antibodyAnti-HKB3 antibodyAnti-MPB3L antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of U-2 OS cells using [KO Validated] ERK2 Rabbit polyclonal antibody (STJ113009) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/92725/373210/STJ113009_1__36729.1713139394.jpg?c=1 "Immunofluorescence analysis of U-2 OS cells using [KO Validated] ERK2 Rabbit polyclonal antibody (STJ113009) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")
