| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC4A1 (1-353) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC4A1 |
| Gene ID: |
6521 |
| Uniprot ID: |
B3AT_HUMAN |
| Immunogen Region: |
1-353 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-353 of human SLC4A1 (NP_000333.1). |
| Immunogen Sequence: |
MEELQDDYEDMMEENLEQEE YEDPDIPESQMEEPAAHDTE ATATDYHTTSHPGTHKVYVE LQELVMDEKNQELRWMEAAR WVQLEENLGENGAWGRPHLS HLTFWSLLELRRVFTKGTVL LDLQETSLAGVANQLLDRFI FEDQIRPQDREELLRALLLK HSHAGELEALGGVKPAVLTR SGDPSQPLLPQHSSLETQLF CEQGDGGTEGHSPSGILEKI PPDSEATLVLVGRADFLEQ |
| Tissue Specificity | Detected in erythrocytes (at protein level). Isoform 2: Expressed in kidney (at protein level). |
| Post Translational Modifications | Phosphorylated on Tyr-8 and Tyr-21 most likely by SYK. PP1-resistant phosphorylation that precedes Tyr-359 and Tyr-904 phosphorylation. Phosphorylated on Tyr-359 and Tyr-904 most likely by LYN. PP1-inhibited phosphorylation that follows Tyr-8 and Tyr-21 phosphorylation. N-glycosylated. |
| Function | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Component of the ankyrin-1 complex of the erythrocyte membrane.required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes. |
| Protein Name | Band 3 Anion Transport ProteinAnion Exchange Protein 1Ae 1Anion Exchanger 1Solute Carrier Family 4 Member 1Cd Antigen Cd233 |
| Database Links | Reactome: R-HSA-1237044Reactome: R-HSA-1247673Reactome: R-HSA-425381Reactome: R-HSA-5619050 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneDetected In The Erythrocyte Cell Membrane And On The Basolateral Membrane Of Alpha-Intercalated Cells In The Collecting Duct In The Kidney |
| Alternative Antibody Names | Anti-Band 3 Anion Transport Protein antibodyAnti-Anion Exchange Protein 1 antibodyAnti-Ae 1 antibodyAnti-Anion Exchanger 1 antibodyAnti-Solute Carrier Family 4 Member 1 antibodyAnti-Cd Antigen Cd233 antibodyAnti-SLC4A1 antibodyAnti-AE1 antibodyAnti-DI antibodyAnti-EPB3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of PC-12 cells using [KO Validated] PTPN2 Rabbit polyclonal antibody (STJ25225) at dilution of 1:200 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/100383/386780/STJ25225_1__40369.1713155922.jpg?c=1 "Immunofluorescence analysis of PC-12 cells using [KO Validated] PTPN2 Rabbit polyclonal antibody (STJ25225) at dilution of 1:200 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")