Anti-SLC47A2 antibody (C-Term) (STJ13102158)

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STJ13102158-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-SLC47A2 (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: SLC47A2
Gene ID: 146802
Uniprot ID: S47A2_HUMAN
Immunogen Region: C-Term
Specificity: Specific for SLC47A2.
Immunogen: A synthetic peptide from c-terminal region of human SLC47A2 conjugated to an immunogenic carrier protein was used as the antigen.
Function Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney. Isoform 6: Non-functional protein.
Protein Name Multidrug And Toxin Extrusion Protein 2
Mate-2
Hmate-2
Kidney-Specific H(+/Organic Cation Antiporter
Solute Carrier Family 47 Member 2
Database Links Reactome: R-HSA-425366
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Detected In The Renal Urinary Tubules
Isoform 6: Apical Cell Membrane
Localized At The Brush Border Membranes Of The Proximal Tubules
Alternative Antibody Names Anti-Multidrug And Toxin Extrusion Protein 2 antibody
Anti-Mate-2 antibody
Anti-Hmate-2 antibody
Anti-Kidney-Specific H(+/Organic Cation Antiporter antibody
Anti-Solute Carrier Family 47 Member 2 antibody
Anti-SLC47A2 antibody
Anti-MATE2 antibody

Information sourced from Uniprot.org

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