Anti-SLC47A1 antibody (460-550) (STJ116770)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC47A1 (460-550) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC47A1 |
| Gene ID | 55244 |
| Uniprot ID | S47A1_HUMAN |
| Immunogen Region | 460-550 |
| Immunogen Sequence | LNWKKACQQAQVHANLKVNN VPRSGNSALPQDPLHPGCPE NLEGILTNDVGKTGEPQSDQ QMRQEEPLPEHPQDGAKLSR KQLVLRRGLLL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 460-550 of human SLC47A1 (NP_060712.2). |
Additional Info
| Tissue Specificity | Widely expressed. The highest expression is found in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney. In testis, primarily localized throughout the adluminal compartment of the seminiferous tubules with expression at the peritubular myoid cells and Leydig cells. |
| Function | Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively. Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate. May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). |
| Protein Name | Multidrug And Toxin Extrusion Protein 1Mate-1Hmate-1Solute Carrier Family 47 Member 1 |
| Database Links | Reactome: R-HSA-425366 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneLocalizes To The Plasma MembraneAt The Brush Border Membranes Of The Proximal Tubules (Kidney) And At The Bile Caniculi (Liver) |
| Alternative Antibody Names | Anti-Multidrug And Toxin Extrusion Protein 1 antibodyAnti-Mate-1 antibodyAnti-Hmate-1 antibodyAnti-Solute Carrier Family 47 Member 1 antibodyAnti-SLC47A1 antibodyAnti-MATE1 antibody |
Information sourced from Uniprot.org