Anti-SLC43A2 antibody (122-172 aa) (STJ193627)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human LAT4 at the amino acid range 122-172
General Information
| Short Description | Rabbit polyclonal anti-Large neutral amino acids transporter small subunit 4 (122-172 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC43A2 |
| Gene ID | 124935 |
| Uniprot ID | LAT4_HUMAN |
| Immunogen | Synthesized peptide derived from the human LAT4 at the amino acid range 122-172 |
| Immunogen Region | 122-172 aa |
| Specificity | This antibody detects endogenous levels of LAT4 at Human/Mouse |
Additional Info
| Post Translational Modifications | Glycosylated. Dephosphorylation at Ser-274 and phosphorylation at Ser-297 increase affinity and amino acid transport activity. Phosphorylation-dephosphorylation cycle is regulated by food-entrained diurnal rhythm and dietary proteins. |
| Function | Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine. The transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent. |
| Protein Name | Large Neutral Amino Acids Transporter Small Subunit 4L-Type Amino Acid Transporter 4Solute Carrier Family 43 Member 2 |
| Database Links | Reactome: R-HSA-352230 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneLocated At The Basolateral Membrane In The Small Intestine EnterocytesKidney Proximal TubuleThick Ascending Limb AndTo A Minor ExtentOf Distal Convoluted Tubule Epithelial Cells |
| Alternative Antibody Names | Anti-Large Neutral Amino Acids Transporter Small Subunit 4 antibodyAnti-L-Type Amino Acid Transporter 4 antibodyAnti-Solute Carrier Family 43 Member 2 antibodyAnti-SLC43A2 antibodyAnti-LAT4 antibodyAnti-PP7664 antibody |
Information sourced from Uniprot.org