Anti-SLC3A1 antibody (Internal Region) (STJ13102153)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from internal region of human Neutral and basic amino acid transport protein rBAT (SLC3A1, D2h) conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-SLC3A1 (Internal Region) for use in IHC and WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | SLC3A1 |
| Gene ID | 6519 |
| Uniprot ID | SLC31_HUMAN |
| Immunogen | A synthetic peptide from internal region of human Neutral and basic amino acid transport protein rBAT (SLC3A1, D2h) conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | Internal Region |
| Specificity | Specific for SLC3A1. |
Additional Info
| Function | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heteromers to the plasma membrane. Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1. SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine. SLC7A9-SLC3A1 acts as a major transporter for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in early proximal tubules. Associates with SLC7A13 to form a functional complex that transports anionic and neutral amino acids via exchange or facilitated diffusion. SLC7A13-SLC3A1 may act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate. |
| Protein Name | Amino Acid Transporter Heavy Chain Slc3a1D2hNeutral And Basic Amino Acid Transport ProteinNbatSolute Carrier Family 3 Member 1B(0 -+-Type Amino Acid Transporter-Related Heavy ChainRbat |
| Database Links | Reactome: R-HSA-352230Reactome: R-HSA-5619113Reactome: R-HSA-5660883 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinApical Cell Membrane |
| Alternative Antibody Names | Anti-Amino Acid Transporter Heavy Chain Slc3a1 antibodyAnti-D2h antibodyAnti-Neutral And Basic Amino Acid Transport Protein antibodyAnti-Nbat antibodyAnti-Solute Carrier Family 3 Member 1 antibodyAnti-B(0 -+-Type Amino Acid Transporter-Related Heavy Chain antibodyAnti-Rbat antibodyAnti-SLC3A1 antibodyAnti-NBAT antibody |
Information sourced from Uniprot.org