Anti-SLC39A4 antibody (STJ13100370)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from human SLC39A4 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-SLC39A4 for use in IHC and WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | SLC39A4 |
| Gene ID | 55630 |
| Uniprot ID | S39A4_HUMAN |
| Immunogen | A synthetic peptide from human SLC39A4 conjugated to blue carrier protein was used as the antigen. |
| Specificity | Specific for SLC39A4. |
Additional Info
| Post Translational Modifications | The extracellular N-terminal ectodomain is cleaved when cells are Zn(2+) deficient, N-terminally cleaved SLC39A4 is internalized at a faster rate. Under excess Zn(2+) conditions, SLC39A4 on the cell surface is rapidly endocytosed, ubiquitinated and degraded. Glycosylated. |
| Function | Selective transporter that mediates the uptake of Zn(2+). Plays an essential role for dietary zinc uptake from small intestine. The Zn(2+) uniporter activity is regulated by zinc availability. Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations. |
| Protein Name | Zinc Transporter Zip4Solute Carrier Family 39 Member 4Zrt- And Irt-Like Protein 4Zip-4 |
| Database Links | Reactome: R-HSA-442380Reactome: R-HSA-5619088 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinRecycling Endosome MembraneApical Cell MembraneColocalized With Tfrc In The Recycling EndosomesCycles Between Endosomal Compartments And The Plasma Membrane In Response To Zn(2+) AvailabilityZn(2+) Deficiency Promotes Accumulation Of Slc39a4 On The Surface MembraneWhereas High Extracellular Zn(2+) Levels Induce Internalization Of Slc39a4But Also Trigger Drastic Removal Of Cellular Slc39a4 Via Proteasomal And Lysosomal Degradation Pathways |
| Alternative Antibody Names | Anti-Zinc Transporter Zip4 antibodyAnti-Solute Carrier Family 39 Member 4 antibodyAnti-Zrt- And Irt-Like Protein 4 antibodyAnti-Zip-4 antibodyAnti-SLC39A4 antibodyAnti-ZIP4 antibody |
Information sourced from Uniprot.org