| Host: |
Rabbit |
| Applications: |
WB/ELISA/IHC |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sodium-coupled neutral amino acid symporter 2 (151-200 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC38A2 |
| Gene ID: |
54407 |
| Uniprot ID: |
S38A2_HUMAN |
| Immunogen Region: |
151-200 aa |
| Specificity: |
SNAT2 Polyclonal Antibody detects endogenous levels of SNAT2 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human SLC38A2 at the amino acid range 151-200 |
| Post Translational Modifications | Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2. |
| Function | Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane. The trasnport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier. May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta. Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate. Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development. |
| Protein Name | Sodium-Coupled Neutral Amino Acid Symporter 2Amino Acid Transporter A2Protein 40-9-1Solute Carrier Family 38 Member 2System A Amino Acid Transporter 2System A Transporter 1System N Amino Acid Transporter 2 |
| Database Links | Reactome: R-HSA-210500Reactome: R-HSA-352230 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInsulin Promotes Recruitment To The Plasma Membrane From A Pool Localized In The Trans-Golgi Network Or EndosomesEnriched In The Somatodendritic Compartment Of NeuronsIt Is Also Detected At The Axonal Shaft But Excluded From The Nerve Terminal |
| Alternative Antibody Names | Anti-Sodium-Coupled Neutral Amino Acid Symporter 2 antibodyAnti-Amino Acid Transporter A2 antibodyAnti-Protein 40-9-1 antibodyAnti-Solute Carrier Family 38 Member 2 antibodyAnti-System A Amino Acid Transporter 2 antibodyAnti-System A Transporter 1 antibodyAnti-System N Amino Acid Transporter 2 antibodyAnti-SLC38A2 antibodyAnti-ATA2 antibodyAnti-KIAA1382 antibodyAnti-SAT2 antibodyAnti-SNAT2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
