| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Proton-coupled zinc antiporter SLC30A5 (106-156 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC30A5 |
| Gene ID: | 64924 |
| Uniprot ID: | ZNT5_HUMAN |
| Immunogen Region: | 106-156 aa |
| Specificity: | This antibody detects endogenous levels of ZNT5 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human ZNT5 at the amino acid range 106-156 |
| Post Translational Modifications | Could homodimerize through the formation of dityrosine bonds upon oxidative stress. |
| Function | Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis. Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin. Isoform 2: Zinc ion:proton antiporter mediating influx and efflux of zinc at the plasma membrane. |
| Protein Name | Proton-Coupled Zinc Antiporter Slc30a5 Solute Carrier Family 30 Member 5 Zinc Transporter 5 Znt-5 Znt-Like Transporter 1 Hztl1 |
| Database Links | Reactome: R-HSA-264876 Reactome: R-HSA-435368 |
| Cellular Localisation | Golgi Apparatus Golgi Stack Membrane Multi-Pass Membrane Protein Cytoplasmic Vesicle Copii-Coated Vesicle Membrane Secretory Vesicle Membrane Trans-Golgi Network Membrane Enriched In Early Compartments Of The Secretory Pathway Including Copii-Coated Vesicles And The Golgi Cis Cisterna Isoform 2: Endoplasmic Reticulum Membrane Cell Membrane Apical Cell Membrane |
| Alternative Antibody Names | Anti-Proton-Coupled Zinc Antiporter Slc30a5 antibody Anti-Solute Carrier Family 30 Member 5 antibody Anti-Zinc Transporter 5 antibody Anti-Znt-5 antibody Anti-Znt-Like Transporter 1 antibody Anti-Hztl1 antibody Anti-SLC30A5 antibody Anti-ZNT5 antibody Anti-ZNTL1 antibody Anti-ZTL1 antibody Anti-UNQ863 antibody Anti-PRO1879 antibody |
Information sourced from Uniprot.org