Anti-SLC30A10 antibody (400-470 aa) (STJ13102227)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 400-470 of mouse SLC30A10 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-SLC30A10 (400-470 aa) for use in IHC and WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:3000 recommended for WB and 1:1000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Slc30a10 |
| Gene ID | 226781 |
| Uniprot ID | ZNT10_MOUSE |
| Immunogen | A synthetic peptide from aa region 400-470 of mouse SLC30A10 conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | 400-470 aa |
| Specificity | Specific for SLC30A10. |
Additional Info
| Function | Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange. Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes. |
| Protein Name | Calcium/Manganese Antiporter Slc30a10Solute Carrier Family 30 Member 10 |
| Database Links | Reactome: R-MMU-425410 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneRecycling Endosome MembraneEarly Endosome MembraneLocalization To The Golgi And Plasma Membrane Is Regulated By Zinc |
| Alternative Antibody Names | Anti-Calcium/Manganese Antiporter Slc30a10 antibodyAnti-Solute Carrier Family 30 Member 10 antibodyAnti-Slc30a10 antibody |
Information sourced from Uniprot.org