Anti-SLC29A3 antibody (2-50 aa) (STJ13102236)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 2-50 of human SLC29A3 conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-SLC29A3 (2-50 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | SLC29A3 |
| Gene ID | 55315 |
| Uniprot ID | S29A3_HUMAN |
| Immunogen | A synthetic peptide from aa region 2-50 of human SLC29A3 conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | 2-50 aa |
| Specificity | Specific for SLC29A3. |
Additional Info
| Function | Uniporter that mediates the facilitative transport of nucleoside across lysosomal and mitochondrial membranes. Functions as a non-electrogenic Na(+)-independent transporter. Substrate transport is pH-dependent and enhanced under acidic condition, probably reflecting the location of the transporter in acidic intracellular compartments. Proton is not a cotransporting ion but most likely change the ionization state of the transporter which dictates transport-permissible/impermissible conformation for nucleoside translocation. May direct the nucleoside transport from lysosomes to cytosol or cytosol to mitochondria to facilitate the fundamental function of salvage synthesis of nucleic acids. Involved in the transport of nucleosides (adenosine, guanosine, uridine, thymidine, cytidine and inosine) and deoxynucleosides (deoxyadenosine, deoxycytidine). Also mediates transport of purine nucleobases (adenine, guanine) and pyrimidine nucleobases (uracil). Also able to transport monoamine neurotransmitters dopamine, serotonin, noradrenaline and tyramine. Capable of transporting ATP. Mediates nucleoside export from lysosomes in macrophages, which regulates macrophage functions and numbers. |
| Protein Name | Equilibrative Nucleoside Transporter 3Hent3Solute Carrier Family 29 Member 3 |
| Database Links | Reactome: R-HSA-5619063Reactome: R-HSA-83936Reactome: R-HSA-9755088 |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinLate Endosome MembraneMitochondrion MembraneCell MembraneObserved In A Punctate Intracellular Pattern Showing Partial Colocalization With Late Endosomes/LysosomesDetected At The Cell Surface Only In Certain Placental Cells |
| Alternative Antibody Names | Anti-Equilibrative Nucleoside Transporter 3 antibodyAnti-Hent3 antibodyAnti-Solute Carrier Family 29 Member 3 antibodyAnti-SLC29A3 antibodyAnti-ENT3 antibodyAnti-UNQ717 antibodyAnti-PRO1380 antibody |
Information sourced from Uniprot.org