Anti-SLC27A4 antibody (43-237) [S4621RM] (STJ11104621)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Long-Chain Fatty Acid Transport Protein 4 (43-237) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4621RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC27A4 |
| Gene ID | 10999 |
| Uniprot ID | S27A4_HUMAN |
| Immunogen Region | 43-237 |
| Immunogen Sequence | RVFIKTIRRDIFGGLVLLKV KAKVRQCLQERRTVPILFAS TVRRHPDKTALIFEGTDTHW TFRQLDEYSSSVANFLQARG LASGDVAAIFMENRNEFVGL WLGMAKLGVEAALINTNLRR DALLHCLTTSRARALVFGSE MASAICEVHASLDPSLSLFC SGSWEPGAVPPSTEHLDPLL KDAPKHLPSCPDKGF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 43-237 of human FATP4/SLC27A4 (NP_005085.2). |
Additional Info
| Tissue Specificity | Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue. Expressed in brain gray matter. |
| Function | Mediates the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across cell membranes. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Probably involved in fatty acid transport across the blood barrier. Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones. |
| Protein Name | Long-Chain Fatty Acid Transport Protein 4Fatp-4Fatty Acid Transport Protein 4Arachidonate--Coa LigaseLong-Chain-Fatty-Acid--Coa LigaseSolute Carrier Family 27 Member 4Very Long-Chain Acyl-Coa Synthetase 4Acsvl4 |
| Database Links | Reactome: R-HSA-5619108Reactome: R-HSA-804914 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Long-Chain Fatty Acid Transport Protein 4 antibodyAnti-Fatp-4 antibodyAnti-Fatty Acid Transport Protein 4 antibodyAnti-Arachidonate--Coa Ligase antibodyAnti-Long-Chain-Fatty-Acid--Coa Ligase antibodyAnti-Solute Carrier Family 27 Member 4 antibodyAnti-Very Long-Chain Acyl-Coa Synthetase 4 antibodyAnti-Acsvl4 antibodyAnti-SLC27A4 antibodyAnti-ACSVL4 antibodyAnti-FATP4 antibody |
Information sourced from Uniprot.org