Anti-SLC25A21 antibody (148-247) (STJ11105232)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Mitochondrial 2-Oxodicarboxylate Carrier (148-247) antibody for use in WB, IHC-P and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC25A21 |
| Gene ID | 89874 |
| Uniprot ID | ODC_HUMAN |
| Immunogen Region | 148-247 |
| Immunogen Sequence | PSTVGYARQIIKKEGWGLQG LNKGLTATLGRHGVFNMVYF GFYYNVKNMIPVNKDPILEF WRKFGIGLLSGTIASVINIP FDVAKSRIQGPQPVPGEIKY |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 148-247 of human SLC25A21 (NP_085134.1). |
Additional Info
| Tissue Specificity | Expressed in placenta, gall bladder and colon. |
| Function | Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle (Probable). |
| Protein Name | Mitochondrial 2-Oxodicarboxylate CarrierOdcMitochondrial 2-Oxoadipate CarrierSolute Carrier Family 25 Member 21 |
| Database Links | Reactome: R-HSA-71064 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial 2-Oxodicarboxylate Carrier antibodyAnti-Odc antibodyAnti-Mitochondrial 2-Oxoadipate Carrier antibodyAnti-Solute Carrier Family 25 Member 21 antibodyAnti-SLC25A21 antibodyAnti-ODC antibody |
Information sourced from Uniprot.org