| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sodium/potassium/calcium exchanger 1/K+/Ca2+-exchange protein 1 (154-203) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC24A1 |
| Gene ID: |
9187 |
| Uniprot ID: |
NCKX1_HUMAN |
| Immunogen Region: |
154-203 |
| Specificity: |
NCKX1 Polyclonal Antibody detects endogenous levels of NCKX1 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human SLC24A1. AA range:154-203 |
| Tissue Specificity | Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer. |
| Post Translational Modifications | The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration. |
| Function | Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. |
| Protein Name | Sodium/Potassium/Calcium Exchanger 1Na(+/K(+/Ca(2+-Exchange Protein 1Retinal Rod Na-Ca+K ExchangerSolute Carrier Family 24 Member 1 |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-425561Reactome: R-HSA-5619077 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium/Potassium/Calcium Exchanger 1 antibodyAnti-Na(+/K(+/Ca(2+-Exchange Protein 1 antibodyAnti-Retinal Rod Na-Ca+K Exchanger antibodyAnti-Solute Carrier Family 24 Member 1 antibodyAnti-SLC24A1 antibodyAnti-KIAA0702 antibodyAnti-NCKX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
