Anti-SLC22A6 antibody (STJA0007498)

SKU:
STJA0007498

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Solute carrier family 22 member 6 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC22A6
Gene ID: 9356
Uniprot ID: S22A6_HUMAN
Specificity: This antibody detects endogenous levels of OAT1 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human OAT1
Post Translational Modifications Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane.
Function Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate. Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion. Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP. Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain. May transport glutamate. Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body. Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate. Xenobiotics include the mycotoxin ochratoxin (OTA). May also contribute to the transport of organic compounds in testes across the blood-testis-barrier.
Protein Name Solute Carrier Family 22 Member 6
Organic Anion Transporter 1
Hoat1
Pah Transporter
Hpaht
Renal Organic Anion Transporter 1
Hroat1
Database Links Reactome: R-HSA-561048
Cellular Localisation Basolateral Cell Membrane
Multi-Pass Membrane Protein
Basal Cell Membrane
Localized To The Basolateral Membrane Of Renal Proximal Tubular Cells
Localized To The Basal Membrane Of Sertoli Cells
Alternative Antibody Names Anti-Solute Carrier Family 22 Member 6 antibody
Anti-Organic Anion Transporter 1 antibody
Anti-Hoat1 antibody
Anti-Pah Transporter antibody
Anti-Hpaht antibody
Anti-Renal Organic Anion Transporter 1 antibody
Anti-Hroat1 antibody
Anti-SLC22A6 antibody
Anti-OAT1 antibody
Anti-PAHT antibody

Information sourced from Uniprot.org

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