Anti-SLC22A17 antibody (Internal) (STJ96427)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the Internal region of human BOCT.
General Information
| Short Description | Rabbit polyclonal anti-Solute carrier family 22 member 17 (Internal) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC22A17 |
| Gene ID | 51310 |
| Uniprot ID | S22AH_HUMAN |
| Immunogen | Synthesized peptide derived from the Internal region of human BOCT. |
| Immunogen Region | Internal |
| Specificity | BOCT Polyclonal Antibody detects endogenous levels of BOCT protein. |
Additional Info
| Function | Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. |
| Protein Name | Solute Carrier Family 22 Member 1724p3 Receptor24p3rBrain-Type Organic Cation TransporterLipocalin-2 ReceptorNeutrophil Gelatinase-Associated Lipocalin ReceptorNgalr |
| Database Links | Reactome: R-HSA-917937 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinVacuole MembraneUpon Lcn2-BindingIt Is Internalized |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 17 antibodyAnti-24p3 Receptor antibodyAnti-24p3r antibodyAnti-Brain-Type Organic Cation Transporter antibodyAnti-Lipocalin-2 Receptor antibodyAnti-Neutrophil Gelatinase-Associated Lipocalin Receptor antibodyAnti-Ngalr antibodyAnti-SLC22A17 antibodyAnti-BOCT antibodyAnti-BOIT antibody |
Information sourced from Uniprot.org