Anti-SLC22A17 antibody (Internal) (STJ71672)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-SLC22A17 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Preliminary experiments gave an approx 150kDa band in Human Cerebellum lysates after 0.1µg/ml antibody staining. Please note that currently we cannot find an explanation in the literat |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC22A17 |
| Gene ID | 51310 |
| Uniprot ID | S22AH_HUMAN |
| Accession Number | NP_065105.2; NP_057693.3 |
| Immunogen Region | Internal |
| Immunogen Sequence | PETKRKLLPEVLRD |
| Specificity | This antibody is expected to recognize both reported isoforms NP_065105.2 and NP_057693.3). |
Additional Info
| Function | Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. |
| Protein Name | Solute Carrier Family 22 Member 1724p3 Receptor24p3rBrain-Type Organic Cation TransporterLipocalin-2 ReceptorNeutrophil Gelatinase-Associated Lipocalin ReceptorNgalr |
| Database Links | Reactome: R-HSA-917937 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinVacuole MembraneUpon Lcn2-BindingIt Is Internalized |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 17 antibodyAnti-24p3 Receptor antibodyAnti-24p3r antibodyAnti-Brain-Type Organic Cation Transporter antibodyAnti-Lipocalin-2 Receptor antibodyAnti-Neutrophil Gelatinase-Associated Lipocalin Receptor antibodyAnti-Ngalr antibodyAnti-SLC22A17 antibodyAnti-BOCT antibodyAnti-BOIT antibody |
Information sourced from Uniprot.org