| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-SLC22A17 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:64000.WB: Preliminary experiments gave an approx 150kDa band in Human Cerebellum lysates after 0.1µg/ml antibody staining. Please note that currently we cannot find an explanation in the literat |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
SLC22A17 |
| Gene ID: |
51310 |
| Uniprot ID: |
S22AH_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_065105.2; NP_057693.3 |
| Specificity: |
This antibody is expected to recognize both reported isoforms NP_065105.2 and NP_057693.3). |
| Immunogen Sequence: |
PETKRKLLPEVLRD |
| Function | Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. |
| Protein Name | Solute Carrier Family 22 Member 1724p3 Receptor24p3rBrain-Type Organic Cation TransporterLipocalin-2 ReceptorNeutrophil Gelatinase-Associated Lipocalin ReceptorNgalr |
| Database Links | Reactome: R-HSA-917937 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinVacuole MembraneUpon Lcn2-BindingIt Is Internalized |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 17 antibodyAnti-24p3 Receptor antibodyAnti-24p3r antibodyAnti-Brain-Type Organic Cation Transporter antibodyAnti-Lipocalin-2 Receptor antibodyAnti-Neutrophil Gelatinase-Associated Lipocalin Receptor antibodyAnti-Ngalr antibodyAnti-SLC22A17 antibodyAnti-BOCT antibodyAnti-BOIT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
