• STJ71290 (0. 3µg/ml) staining of KELLY lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-DLG1 antibody (Internal) (STJ71290)

SKU:
STJ71290-100

£303.50
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Host: Goat
Applications: Pep-ELISA/IF/FC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-DLG1 (Internal) is suitable for use in ELISA, Immunofluorescence and Flow Cytometry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.3-1µg/ml
ELISA-antibody detection limit dilution 1:16000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: DLG1
Gene ID: 1739
Uniprot ID: DLG1_HUMAN
Immunogen Region: Internal
Accession Number: NP_001091894.1; NP_004078.2
Specificity: This antibody is expected to recognize both reported isoforms (NP_001091894.1and NP_004078.2).
Immunogen Sequence: NSKTRDKGEIPDD
Post Translational Modifications Phosphorylated by MAPK12. Phosphorylation of Ser-232 regulates association with GRIN2A. Ubiquitinated.by MARCHF2 which results in its degradation.
Function Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane.
Protein Name Disks Large Homolog 1
Synapse-Associated Protein 97
Sap-97
Sap97
Hdlg
Database Links Reactome: R-HSA-399719
Reactome: R-HSA-438066
Reactome: R-HSA-442982
Reactome: R-HSA-447038
Reactome: R-HSA-451308
Reactome: R-HSA-5673001
Reactome: R-HSA-8849932
Reactome: R-HSA-9609736
Reactome: R-HSA-9617324
Reactome: R-HSA-9620244
Cellular Localisation Membrane
Peripheral Membrane Protein
Basolateral Cell Membrane
Endoplasmic Reticulum Membrane
Postsynaptic Density
Synapse
Cell Membrane
Sarcolemma
Apical Cell Membrane
Cell Junction
Cytoplasm
Colocalizes With Epb41 At Regions Of Intercellular Contacts
Basolateral In Epithelial Cells
May Also Associate With Endoplasmic Reticulum Membranes
Mainly Found In Neurons Soma
Moderately Found At Postsynaptic Densities
Alternative Antibody Names Anti-Disks Large Homolog 1 antibody
Anti-Synapse-Associated Protein 97 antibody
Anti-Sap-97 antibody
Anti-Sap97 antibody
Anti-Hdlg antibody
Anti-DLG1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance