| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC22A11 (40-140) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC22A11 |
| Gene ID: |
55867 |
| Uniprot ID: |
S22AB_HUMAN |
| Immunogen Region: |
40-140 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-140 of human SLC22A11 (NP_060954.1). |
| Immunogen Sequence: |
FSAAIPGHRCWTHMLDNGSA VSTNMTPKALLTISIPPGPN QGPHQCRRFRQPQWQLLDPN ATATSWSEADTEPCVDGWVY DRSVFTSTIVAKWDLVCSSQ G |
| Tissue Specificity | Expressed in placental trophoblasts, syncytiotrophoblast and cytotrophoblast. Also located in the proximal tubules in kidneys. |
| Post Translational Modifications | N-glycosylated. Contains several complex-type N-glycans. |
| Function | Antiporter that mediates the transport of conjugated steroids and other specific organic anions at the basal membrane of syncytiotrophoblast and at the apical membrane of proximal tubule epithelial cells, in exchange for anionic compounds. May be responsible for placental absorption of fetal-derived steroid sulfates such as estrone sulfate (E1S) and the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S), as well as clearing waste products and xenobiotics from the fetus. Maybe also be involved in placental urate homeostasis. Facilitates the renal reabsorption of organic anions such as urate and derived steroid sulfates. Organic anion glutarate acts as conteranion for E1S renal uptake. Possible transport mode may also include DHEA-S/E1S exchange. Also interacts with inorganic anions such as chloride and hydroxyl ions, therefore possible transport modes may include E1S/Cl(-), E1S/OH(-), urate/Cl(-) and urate/OH(-). Also mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion. Also able to uptake anionic drugs, diuretics, bile salts and ochratoxin A. Mediates the unidirectional efflux of glutamate and aspartate. Glutamate efflux down its transmembrane gradient may drive SLC22A11/OAT4-mediated placental uptake of E1S. |
| Protein Name | Solute Carrier Family 22 Member 11Organic Anion Transporter 4Oat4Organic Anion -Dicarboxylate Exchanger Oat4 |
| Database Links | Reactome: R-HSA-561048 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneBasal Cell MembraneExpressed At The Apical Membrane Of The Proximal Tubule Epithelial CellsExpressed At The Basal Membrane Of The Syncytiotrophoblast |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 11 antibodyAnti-Organic Anion Transporter 4 antibodyAnti-Oat4 antibodyAnti-Organic Anion -Dicarboxylate Exchanger Oat4 antibodyAnti-SLC22A11 antibodyAnti-OAT4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
