| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC1A7 (ECD) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
SLC1A7 |
| Gene ID: |
6512 |
| Uniprot ID: |
EAA5_HUMAN |
| Immunogen Region: |
ECD |
| Specificity: |
Specific for EAAT5. |
| Immunogen: |
A synthetic peptide from extracellular domain of human Excitatory amino acid transporter 5 (EAAT5, SLC1A7) conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Acts primarily as an inhibitory glutamate-gated chloride channel being a major inhibitory presynaptic receptor at mammalian rod bipolar cell axon terminals. Glutamate binding gates a large Cl(-) conductance that mediates inhibition, affecting visual processing in the retina. |
| Protein Name | Excitatory Amino Acid Transporter 5Retinal Glutamate TransporterSolute Carrier Family 1 Member 7 |
| Database Links | Reactome: R-HSA-210500Reactome: R-HSA-425393 |
| Cellular Localisation | Photoreceptor Inner Segment MembraneMulti-Pass Membrane ProteinSynaptic Cell MembraneLocated In Both Cone And Rod Photoreceptor Terminals And In Axon Terminals Of Rod Bipolar Cells |
| Alternative Antibody Names | Anti-Excitatory Amino Acid Transporter 5 antibodyAnti-Retinal Glutamate Transporter antibodyAnti-Solute Carrier Family 1 Member 7 antibodyAnti-SLC1A7 antibodyAnti-EAAT5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
