| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC1A5 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC1A5 |
| Gene ID: |
6510 |
| Uniprot ID: |
AAAT_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human SLC1A5 (NP_005619.1). |
| Immunogen Sequence: |
MVADPPRDSKGLAAAEPTAN GGLALASIEDQGAAAGGYCG SRDQVRRCLRANLLVLLTVV AVVAGVALGLGVSGAGGALA LGPERLSAFVFPGELLLRLL |
| Tissue Specificity | Placenta, lung, skeletal muscle, kidney, pancreas, and intestine. Expressed in CD34-positive hematopoietic progenitors (at protein level). |
| Function | Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion. The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation. The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system. Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons. Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development. (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. |
| Protein Name | Neutral Amino Acid Transporter B(0Atb(0Baboon M7 Virus ReceptorRd114/Simian Type D Retrovirus ReceptorSodium-Dependent Neutral Amino Acid Transporter Type 2Solute Carrier Family 1 Member 5 |
| Database Links | Reactome: R-HSA-352230Reactome: R-HSA-9013149Reactome: R-HSA-9013406Reactome: R-HSA-9013407Reactome: R-HSA-9013409Reactome: R-HSA-9013423 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Neutral Amino Acid Transporter B(0 antibodyAnti-Atb(0 antibodyAnti-Baboon M7 Virus Receptor antibodyAnti-Rd114/Simian Type D Retrovirus Receptor antibodyAnti-Sodium-Dependent Neutral Amino Acid Transporter Type 2 antibodyAnti-Solute Carrier Family 1 Member 5 antibodyAnti-SLC1A5 antibodyAnti-ASCT2 antibodyAnti-M7V1 antibodyAnti-RDR antibodyAnti-RDRC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
