| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC1A1 (430-524) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC1A1 |
| Gene ID: |
6505 |
| Uniprot ID: |
EAA3_HUMAN |
| Immunogen Region: |
430-524 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 430-524 of human SLC1A1 (NP_004161.4). |
| Immunogen Sequence: |
AEDVTLIIAVDWLLDRFRTM VNVLGDAFGTGIVEKLSKKE LEQMDVSSEVNIVNPFALES TILDNEDSDTKKSYVNGGFA VDKSDTISFTQTSQF |
| Tissue Specificity | Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers). |
| Post Translational Modifications | Glycosylated. |
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport.this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport. Negatively regulated by ARL6IP5. |
| Protein Name | Excitatory Amino Acid Transporter 3Excitatory Amino-Acid Carrier 1Neuronal And Epithelial Glutamate TransporterSodium-Dependent Glutamate/Aspartate Transporter 3Solute Carrier Family 1 Member 1 |
| Database Links | Reactome: R-HSA-210500Reactome: R-HSA-425393Reactome: R-HSA-5619067 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneSynapseSynaptosomeEarly Endosome MembraneLate Endosome MembraneRecycling Endosome Membrane |
| Alternative Antibody Names | Anti-Excitatory Amino Acid Transporter 3 antibodyAnti-Excitatory Amino-Acid Carrier 1 antibodyAnti-Neuronal And Epithelial Glutamate Transporter antibodyAnti-Sodium-Dependent Glutamate/Aspartate Transporter 3 antibodyAnti-Solute Carrier Family 1 Member 1 antibodyAnti-SLC1A1 antibodyAnti-EAAC1 antibodyAnti-EAAT3 antibodyAnti-HEAAC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
