Anti-SLC1A1 antibody (150-200 aa) (STJ13101072)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from extracellular domain of human EAAT3 (aa region 150-200) conjugated to blue carrier protein was used as the antigen. The peptide shares 96% identity with rat and mouse sequence.
General Information
| Short Description | Rabbit polyclonal anti-SLC1A1 (150-200 aa) for use in IHC and WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A concentration of 10-50 ยตg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | SLC1A1 |
| Gene ID | 6505 |
| Uniprot ID | EAA3_HUMAN |
| Immunogen | A synthetic peptide from extracellular domain of human EAAT3 (aa region 150-200) conjugated to blue carrier protein was used as the antigen. The peptide shares 96% identity with rat and mouse sequence. |
| Immunogen Region | 150-200 aa |
| Specificity | Specific for EAAT3. |
Additional Info
| Post Translational Modifications | Glycosylated. |
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport.this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport. Negatively regulated by ARL6IP5. |
| Protein Name | Excitatory Amino Acid Transporter 3Excitatory Amino-Acid Carrier 1Neuronal And Epithelial Glutamate TransporterSodium-Dependent Glutamate/Aspartate Transporter 3Solute Carrier Family 1 Member 1 |
| Database Links | Reactome: R-HSA-210500Reactome: R-HSA-425393Reactome: R-HSA-5619067 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneSynapseSynaptosomeEarly Endosome MembraneLate Endosome MembraneRecycling Endosome Membrane |
| Alternative Antibody Names | Anti-Excitatory Amino Acid Transporter 3 antibodyAnti-Excitatory Amino-Acid Carrier 1 antibodyAnti-Neuronal And Epithelial Glutamate Transporter antibodyAnti-Sodium-Dependent Glutamate/Aspartate Transporter 3 antibodyAnti-Solute Carrier Family 1 Member 1 antibodyAnti-SLC1A1 antibodyAnti-EAAC1 antibodyAnti-EAAT3 antibodyAnti-HEAAC1 antibody |
Information sourced from Uniprot.org