Anti-SLC19A1 antibody (452-591) (STJ114685)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC19A1 (452-591) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC19A1 |
| Gene ID | 6573 |
| Uniprot ID | S19A1_HUMAN |
| Immunogen Region | 452-591 |
| Immunogen Sequence | LDGLRHCQRGHHPRQPPAQG LRSAAEEKAAQALSVQDKGL GGLQPAQSPPLSPEDSLGAV GPASLEQRQSDPYLAQAPAP QAAEFLSPVTTPSPCTLCSA QASGPEAADETCPQLAVHPP GVSKLGLQCLPSDGVQNVNQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 452-591 of human SLC19A1 (NP_919231.1). |
Additional Info
| Tissue Specificity | Placenta, liver, and to a much smaller extent, in lung. |
| Function | Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions. Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses. Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also mediates the import of antifolate drug methotrexate. 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity. |
| Protein Name | Reduced Folate TransporterFoltCyclic Dinucleotide -Anion Antiporter Slc19a1Folate -Anion Antiporter Slc19a1Intestinal Folate Carrier 1Ifc-1Placental Folate TransporterReduced Folate Carrier ProteinRfcHrfcReduced Folate Transporter 1Rft-1Solute Carrier Family 19 Member 1Hslc19a1 |
| Database Links | Reactome: R-HSA-196757 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneBasolateral Cell Membrane |
| Alternative Antibody Names | Anti-Reduced Folate Transporter antibodyAnti-Folt antibodyAnti-Cyclic Dinucleotide -Anion Antiporter Slc19a1 antibodyAnti-Folate -Anion Antiporter Slc19a1 antibodyAnti-Intestinal Folate Carrier 1 antibodyAnti-Ifc-1 antibodyAnti-Placental Folate Transporter antibodyAnti-Reduced Folate Carrier Protein antibodyAnti-Rfc antibodyAnti-Hrfc antibodyAnti-Reduced Folate Transporter 1 antibodyAnti-Rft-1 antibodyAnti-Solute Carrier Family 19 Member 1 antibodyAnti-Hslc19a1 antibodyAnti-SLC19A1 antibodyAnti-FLOT1 antibodyAnti-RFC1 antibody |
Information sourced from Uniprot.org