• Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-SLC17A7 antibody (488-538 aa) (STJ193539)

SKU:
STJ193539

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Vesicular glutamate transporter 1-dependent inorganic phosphate cotransporter (488-538 aa) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC17A7
Gene ID: 57030
Uniprot ID: VGLU1_HUMAN
Immunogen Region: 488-538 aa
Specificity: This antibody detects endogenous levels of VGLU1 at Human/Mouse/Rat
Immunogen: Synthesized peptide derived from the human VGLU1 at the amino acid range 488-538
Function Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate. At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane. In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification. Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake. The vesicular K(+)/H(+) antiport activity is electroneutral. At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation. The symporter activity is driven by an inside negative membrane potential and is electrogenic. Is necessary for synaptic signaling of visual-evoked responses from photoreceptors.
Protein Name Vesicular Glutamate Transporter 1
Vglut1
Brain-Specific Na(+-Dependent Inorganic Phosphate Cotransporter
Solute Carrier Family 17 Member 7
Database Links Reactome: R-HSA-210500
Reactome: R-HSA-428643
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle Membrane
Cell Membrane
Multi-Pass Membrane Protein
Synapse
Synaptosome
Alternative Antibody Names Anti-Vesicular Glutamate Transporter 1 antibody
Anti-Vglut1 antibody
Anti-Brain-Specific Na(+-Dependent Inorganic Phosphate Cotransporter antibody
Anti-Solute Carrier Family 17 Member 7 antibody
Anti-SLC17A7 antibody
Anti-BNPI antibody
Anti-VGLUT1 antibody

Information sourced from Uniprot.org

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