• Western blot analysis of various lysates using SLC17A5 Rabbit polyclonal antibody (STJ117621) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Anti-SLC17A5 antibody (1-100) (STJ117621)

SKU:
STJ117621

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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SLC17A5 (1-100) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:200-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC17A5
Gene ID: 26503
Uniprot ID: S17A5_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC17A5 (NP_036566.1).
Immunogen Sequence: MRSPVRDLARNDGEESTDRT PLLPGAPRAEAAPVCCSARY NLAILAFFGFFIVYALRVNL SVALVDMVDSNTTLEDNRTS KACPEHSAPIKVHHNQTGKK
Tissue Specificity In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues. Highly expressed in salivary glands and liver, with lower levels of expression in brain, spleen kidney, muscle and pancreas. Expressed in acinar cells of salivary glands (at protein level).
Function Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport. Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system. Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva. Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release. Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties.
Protein Name Sialin
H(+/Nitrate Cotransporter
H(+/Sialic Acid Cotransporter
Ast
Membrane Glycoprotein Hp59
Solute Carrier Family 17 Member 5
Vesicular Excitatory Amino Acid Transporter
Veat
Database Links Reactome: R-HSA-4085001
Reactome: R-HSA-428643
Reactome: R-HSA-5619035
Cellular Localisation Basolateral Cell Membrane
Multi-Pass Membrane Protein
Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle Membrane
Lysosome Membrane
Alternative Antibody Names Anti-Sialin antibody
Anti-H(+/Nitrate Cotransporter antibody
Anti-H(+/Sialic Acid Cotransporter antibody
Anti-Ast antibody
Anti-Membrane Glycoprotein Hp59 antibody
Anti-Solute Carrier Family 17 Member 5 antibody
Anti-Vesicular Excitatory Amino Acid Transporter antibody
Anti-Veat antibody
Anti-SLC17A5 antibody

Information sourced from Uniprot.org

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