Anti-SLC13A5 antibody (150-230 aa) (STJ13102229)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 150-230 of human SLC13A5 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-SLC13A5 (150-230 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | SLC13A5 |
| Gene ID | 284111 |
| Uniprot ID | S13A5_HUMAN |
| Immunogen | A synthetic peptide from aa region 150-230 of human SLC13A5 conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | 150-230 aa |
| Specificity | Specific for SLC13A5. |
Additional Info
| Function | High-affinity sodium/citrate cotransporter that mediates the entry of citrate into cells, which is a critical participant of biochemical pathways. May function in various metabolic processes in which citrate has a critical role such as energy production (Krebs cycle), fatty acid synthesis, cholesterol synthesis, glycolysis, and gluconeogenesis. Transports citrate into the cell in a Na(+)-dependent manner, recognizing the trivalent form of citrate (physiological pH) rather than the divalent form. Can recognize succinate as a substrate, but its affinity for succinate is several fold lower than for citrate. The stoichiometry is probably 4 Na(+) for each carboxylate, irrespective of whether the translocated substrate is divalent or trivalent, rendering the process electrogenic. Involved in the regulation of citrate levels in the brain. |
| Protein Name | Na(+/Citrate CotransporterNactSodium-Coupled Citrate TransporterSodium-Dependent Citrate TransporterSolute Carrier Family 13 Member 5 |
| Database Links | Reactome: R-HSA-433137 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Na(+/Citrate Cotransporter antibodyAnti-Nact antibodyAnti-Sodium-Coupled Citrate Transporter antibodyAnti-Sodium-Dependent Citrate Transporter antibodyAnti-Solute Carrier Family 13 Member 5 antibodyAnti-SLC13A5 antibodyAnti-NACT antibody |
Information sourced from Uniprot.org