Anti-SLC13A3 antibody (STJA0008232)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SLC13A3
General Information
| Short Description | Rabbit polyclonal anti-Na+/dicarboxylate cotransporter 3-coupled carboxylate transporter 3 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC13A3 |
| Gene ID | 64849 |
| Uniprot ID | S13A3_HUMAN |
| Immunogen | Synthesized peptide derived from human SLC13A3 |
| Specificity | This antibody detects endogenous levels of SLC13A3 at Human, Mouse, Rat |
Additional Info
| Function | High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate. Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic. Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood. Imports itaconate in hepatocytes leading to activation of TFEB-dependent lysosomal biogenesis involved in antibacterial innate immune response. |
| Protein Name | Na(+/Dicarboxylate Cotransporter 3Nadc-3Hnadc3Na(+-Coupled Carboxylate Transporter 3Nac3Sodium-Dependent High-Affinity Dicarboxylate Transporter 2Solute Carrier Family 13 Member 3Slc13a3 |
| Database Links | Reactome: R-HSA-433137 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Na(+/Dicarboxylate Cotransporter 3 antibodyAnti-Nadc-3 antibodyAnti-Hnadc3 antibodyAnti-Na(+-Coupled Carboxylate Transporter 3 antibodyAnti-Nac3 antibodyAnti-Sodium-Dependent High-Affinity Dicarboxylate Transporter 2 antibodyAnti-Solute Carrier Family 13 Member 3 antibodyAnti-Slc13a3 antibodyAnti-SLC13A3 antibodyAnti-NADC3 antibodyAnti-SDCT2 antibody |
Information sourced from Uniprot.org