Anti-SLC12A7 antibody (1-70) (STJ114187)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC12A7 (1-70) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC12A7 |
| Gene ID | 10723 |
| Uniprot ID | S12A7_HUMAN |
| Immunogen Region | 1-70 |
| Immunogen Sequence | MPTNFTVVPVEAHADGGGDE TAERTEAPGTPEGPEPERPS PGDGNPRENSPFLNNVEVEQ ESFFEGKNMA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human SLC12A7 (NP_006589.2). |
Additional Info
| Tissue Specificity | Detected in muscle, brain, lung, heart and kidney. |
| Function | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification. |
| Protein Name | Solute Carrier Family 12 Member 7Electroneutral Potassium-Chloride Cotransporter 4K-Cl Cotransporter 4 |
| Database Links | Reactome: R-HSA-426117 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Solute Carrier Family 12 Member 7 antibodyAnti-Electroneutral Potassium-Chloride Cotransporter 4 antibodyAnti-K-Cl Cotransporter 4 antibodyAnti-SLC12A7 antibodyAnti-KCC4 antibody |
Information sourced from Uniprot.org