Anti-SLC12A2 antibody (Internal) (STJ72112)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-SLC12A2 (Internal) is suitable for use in ELISA, Immunohistochemistry, Immunofluorescence and Flow Cytometry research applications. |
| Applications | Pep-ELISA/IHC/IF/FC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.IHC: In paraffin embedded Human Colon shows membranous staining. Recommended concentration: 3.75µg/ml.IF: Strong expression of the protein seen in the cytoplasm/vesicles of HeLa cells |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC12A2 |
| Gene ID | 6558 |
| Uniprot ID | S12A2_HUMAN |
| Accession Number | NP_001037.1; NP_001243390.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | NALQHSIRLSGVEDH |
Additional Info
| Post Translational Modifications | Phosphorylated at Thr-203, Thr-207 and Thr-212 by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4), promoting its activity. |
| Function | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume. |
| Protein Name | Solute Carrier Family 12 Member 2Basolateral Na-K-Cl SymporterBumetanide-Sensitive Sodium-(Potassium-Chloride Cotransporter 2Bsc2Na-K-2cl Cotransporter 1Hnkcc1 |
| Database Links | Reactome: R-HSA-426117 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Solute Carrier Family 12 Member 2 antibodyAnti-Basolateral Na-K-Cl Symporter antibodyAnti-Bumetanide-Sensitive Sodium-(Potassium-Chloride Cotransporter 2 antibodyAnti-Bsc2 antibodyAnti-Na-K-2cl Cotransporter 1 antibodyAnti-Hnkcc1 antibodyAnti-SLC12A2 antibodyAnti-NKCC1 antibody |
Information sourced from Uniprot.org