| Host: |
Mouse |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-S-phase kinase-associated protein 2 (1-130 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
6G9D10 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SKP2 |
| Gene ID: |
6502 |
| Uniprot ID: |
SKP2_HUMAN |
| Immunogen Region: |
1-130 aa |
| Specificity: |
Skp2 p45 Monoclonal Antibody detects endogenous levels of Skp2 p45 protein. |
| Immunogen: |
Purified recombinant fragment of Skp2 p45 (aa1-130) expressed in E. Coli. |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration. Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. |
| Protein Name | S-Phase Kinase-Associated Protein 2Cyclin-A/Cdk2-Associated Protein P45F-Box Protein Skp2F-Box/Lrr-Repeat Protein 1P45skp2 |
| Database Links | Reactome: R-HSA-174178Reactome: R-HSA-187577Reactome: R-HSA-5689880Reactome: R-HSA-68949Reactome: R-HSA-69231Reactome: R-HSA-8939902Reactome: R-HSA-8951664Reactome: R-HSA-9687136Reactome: R-HSA-9708530Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-S-Phase Kinase-Associated Protein 2 antibodyAnti-Cyclin-A/Cdk2-Associated Protein P45 antibodyAnti-F-Box Protein Skp2 antibodyAnti-F-Box/Lrr-Repeat Protein 1 antibodyAnti-P45skp2 antibodyAnti-SKP2 antibodyAnti-FBXL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
