Anti-SKAP1 antibody (STJ192105)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Src kinase-associated phosphoprotein 1 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SKAP1 |
| Gene ID | 8631 |
| Uniprot ID | SKAP1_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | SKAP1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB1. Tyr-232 is dephosphorylated by PTPRC (Probable). |
| Function | Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. |
| Protein Name | Src Kinase-Associated Phosphoprotein 1Src Family-Associated Phosphoprotein 1Src Kinase-Associated Phosphoprotein Of 55 KdaSkap-55Pp55 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusCell MembraneUpon T-Cell StimulationTranslocates To Lipid Rafts At The Cell Membrane |
| Alternative Antibody Names | Anti-Src Kinase-Associated Phosphoprotein 1 antibodyAnti-Src Family-Associated Phosphoprotein 1 antibodyAnti-Src Kinase-Associated Phosphoprotein Of 55 Kda antibodyAnti-Skap-55 antibodyAnti-Pp55 antibodyAnti-SKAP1 antibodyAnti-SCAP1 antibodyAnti-SKAP55 antibody |
Information sourced from Uniprot.org