Anti-SIVA1 antibody (1-110) (STJ28248)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SIVA1 (1-110) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SIVA1 |
| Gene ID | 10572 |
| Uniprot ID | SIVA_HUMAN |
| Immunogen Region | 1-110 |
| Immunogen Sequence | MPKRSCPFADVAPLQLKVRV SQRELSRGVCAERYSQEVFD PSGVASIACSSCVRAVDGKA VCGQCERALCGQCVRTCWGC GSVACTLCGLVDCSDMYEKV LCTSCAMFET |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human SIVA1 (NP_068355.1). |
Additional Info
| Tissue Specificity | Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon. |
| Post Translational Modifications | Phosphorylated by ABL2/ARG in response to oxidative stress. |
| Function | Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. |
| Protein Name | Apoptosis Regulatory Protein SivaCd27-Binding ProteinCd27bp |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusIn The NucleusAccumulates In Dot-Like Structures |
| Alternative Antibody Names | Anti-Apoptosis Regulatory Protein Siva antibodyAnti-Cd27-Binding Protein antibodyAnti-Cd27bp antibodyAnti-SIVA1 antibodyAnti-SIVA antibody |
Information sourced from Uniprot.org