Anti-SIGLEC8/SAF-2 antibody [SAA0177] {PE} (STJA0031695)
SPECIFICATIONS
ClonalityMonoclonal
HostHuman
ConjugationPE
IsotypeIgG1k
General Information
| Short Description | Human monoclonal Sialic Acid-Binding Ig-Like Lectin 8 antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Human |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0177 |
| Isotype | IgG1k |
| Conjugation | PE |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | SIGLEC8 |
| Gene ID | 27181 |
| Uniprot ID | SIGL8_HUMAN |
Additional Info
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes. |
| Protein Name | Sialic Acid-Binding Ig-Like Lectin 8Siglec-8Sialoadhesin Family Member 2Saf-2 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Sialic Acid-Binding Ig-Like Lectin 8 antibodyAnti-Siglec-8 antibodyAnti-Sialoadhesin Family Member 2 antibodyAnti-Saf-2 antibodyAnti-SIGLEC8 antibodyAnti-SAF2 antibody |
Information sourced from Uniprot.org